Is the glue treatment better than laser for varicose veins?
Equivalent on the main outcome, more comfortable afterwards. In a systematic review and meta-analysis of 21 studies covering 7,844 patients and 9,677 limbs, cyanoacrylate ablation and endovenous radiofrequency ablation showed no significant difference in great saphenous vein occlusion rate or Venous Clinical Severity Score, while cyanoacrylate produced less ecchymosis (5.96 against 10.97 percent, P = .01), less paraesthesia (1.24 against 2.97 percent, P = .04) and a shorter procedure time — but rare serious harms specific to the glue, including a fatal pulmonary embolism and a severe granuloma, appear only as case reports and are not counted in that comparison.