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Sexual Health

Syphilis cases in Korea jumped in 2024. Did the disease spread, or did the counting change?

Korea switched syphilis from sentinel reporting to mandatory reporting on 1 January 2024 and widened the criteria at the same time. The rise was already happening, and the 2024 number still cannot be compared with the 2019 one.

Answer

Both changed, and the counting is the half usually left out: on 1 January 2024 Korea moved syphilis from sentinel surveillance, in which a designated sample of sites report, to mandatory surveillance, in which every diagnosed case must be reported, and expanded the reporting criteria at the same time — so the 2,790 cases and incidence of 5.4 per 100,000 recorded for 2024 were not measured the way the 3.41 per 100,000 reported for 2019 was, and subtracting one from the other measures the change in the system as much as the change in the disease; the underlying rise is nevertheless real, having climbed from 1.93 per 100,000 in 2011 to 3.41 in 2019 under the old system and risen sharply in men in their twenties and thirties since 2016, which is precisely where the 2024 cases concentrate.

Key takeaways

  • Korea transitioned syphilis surveillance from sentinel to mandatory reporting in 2024 and expanded the reporting criteria at the same time. Counts before and after that line are not measured the same way.
  • Under the new system, 2,790 syphilis cases were reported in 2024, an incidence of 5.4 per 100,000 population.
  • Under the old system the reported rate had already risen steadily, from 1.93 per 100,000 in 2011 to 3.41 per 100,000 in 2019, rising sharply among men in their twenties and thirties from 2016.
  • Of the 2024 cases, 78.0 percent were male. Incidence in men was 8.5 per 100,000 against 2.4 in women, a 3.5-fold difference.
  • Cases concentrated in the twenties (853 cases, 30.6 percent) and thirties (783, 28.1 percent), with the highest incidence of any age group in the twenties at 14.0 per 100,000.
  • Early latent syphilis was the single largest stage at 1,220 cases (43.7 percent) — infection found in people who had no symptoms at the time.
  • Twelve cases of congenital syphilis were reported, 0.4 percent of the total.
  • The capital area accounted for 1,631 cases, 58.5 percent of the national total, and imported infections for 117 cases, 4.2 percent.

Two things happened to syphilis in Korea in 2024. One is that more of it was found. The other is that the country changed how it looks, and the second is what makes the first hard to size.

What changed on 1 January 2024

Until the end of 2023, syphilis was under sentinel surveillance: a designated sample of reporting sites submitted cases, and the national figure was estimated from them. From 2024 it moved to mandatory surveillance, in which every diagnosed case is reported through the Korea Disease Control and Prevention Agency's integrated system. The reporting criteria were widened in the same move.

Both changes push the recorded number in the same direction, independently of whether a single additional person was infected. A system that counts everything finds more than a system that counts a sample, and broader criteria admit cases the narrower ones excluded.

What the 2024 count actually contains

The first year of mandatory reporting recorded 2,790 confirmed cases and pathogen carriers, an incidence of 5.4 per 100,000. The distribution is the useful part.

  • Early latent syphilis, 1,220 cases (43.7 percent) — the largest single stage.
  • Primary syphilis, 983 cases (35.2 percent).
  • Secondary syphilis, 524 cases (18.8 percent).
  • Tertiary syphilis, 51 cases (1.8 percent).
  • Congenital syphilis, 12 cases (0.4 percent).

78.0%

of the 2,790 syphilis cases reported in Korea in 2024 were in men; incidence 8.5 per 100,000 in men against 2.4 in women

Cases clustered in the twenties (853, 30.6 percent) and thirties (783, 28.1 percent), and the twenties carried the highest incidence of any age group at 14.0 per 100,000. The capital area held 1,631 cases, 58.5 percent of the national total. Infections acquired abroad accounted for 117 cases, 4.2 percent — a small share, and worth stating because it is often assumed to be a large one.

The rise that was already there

The surveillance change does not mean nothing was happening. Measured consistently under the old system, the reported rate climbed from 1.93 per 100,000 in 2011 to 3.41 per 100,000 in 2019, and the increase was sharpest in men in their twenties and thirties from 2016 onwards. That is the same group the 2024 data concentrates in, which is the reason to treat the trend as real even though the size of the jump is not readable.

It also sits inside a wider pattern. Across Korean insurance data from 2010 to 2021, bacterial sexually transmitted infections were generally declining while viral ones rose. Syphilis moving the other way is what makes it worth separate attention.

The number that matters most for an individual

Early latent syphilis being the largest stage is the finding with the most direct consequence. Latent means no symptoms at the time of diagnosis: these are infections found by a test rather than by a complaint. Korean guidelines describe syphilis as progressing through primary, secondary, latent and tertiary stages, with the chronic form capable of affecting almost any organ, and untreated maternal infection as capable of causing fetal death and severe congenital disease.

Twelve congenital cases in a year is a small number and not a zero. Every one of them began as an infection in a pregnancy that a test would have found.

The practical reading is narrow and firm. A rise in reported syphilis in Korea is partly an artefact of better counting and partly a real increase that predates the counting change; the group it concentrates in is young men in and around Seoul; and the commonest stage at diagnosis is the one with nothing to notice, which is an argument for testing rather than for waiting to see something.

Sources

  1. Kim EY, Han S, Yu J

    Epidemiological characteristics of syphilis in the Republic of Korea in 2024
  2. Kim DY, Park KH

    Updates on epidemiology and diagnostic tests of syphilis in South Korea
  3. Choi J, Choi JB, Bae S, Lee CH, Shin YS, You D, Lee JY, Lee SJ, et al.

    2023 Korean sexually transmitted infections guidelines for non-gonococcal bacterial infection (chlamydia, syphilis, etc.) by the Korean Association of Urogenital Tract Infection and Inflammation
  4. Song JY, Kim KS, Han CH, Bae S

    Recent changes in sexually transmitted infection in Korea: a population-based analysis